That is everything you need to know on how to use items in Binding of Isaac. Pick Ups: These are miscellaneous collectibles in the game such as keys, hearts, coins and bombs that you get as loot from killing monsters and find on excavation.All you need to do is pick up a Trinet to instantly get its effect. Trinkets: These are special and rare items that act as a passive skill in their own place.These have the same key as Cards so you have to press Q. There is just one slot for Tarot Cards and Pills so you can only carry one at a time. Pills: These are more commonly found items that give you buffs that can also be used just once.You can use Tarot Cards by pressing the Q button. Tarot Cards share the same slot as Pills so you can only have one of either at once. Tarot Card: These mysterious cards that give you a random power-up to use once.Activated items can be used by pressing the SpaceBar on PC and L2 button for consoles. Activated Items: These are rare items that provide elusive power-ups that can be used multiple times with a cooldown time.Passive: These are unique permanent buffs applied to Isaac and applied automatically.Here are all the types of items in Binding of Isaac and how you can use them: Items help in various different ways depending on their types. Items are essential in this game because there are only a limited supply of bombs you can use to do damage and clear out areas.
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